Tesamorelin protocol
Tesamorelin (stabilised GHRH analog). Dosing on this page comes from a published human trial or an approved product label, cited below.
How Tesamorelin works
A GHRH analog with a trans-3-hexenoyl group added to the N-terminus, which protects it from degradation by dipeptidyl peptidase-4 and extends its activity relative to unmodified GHRH.
Tesamorelin dosing schedule
From the approved label. Tesamorelin is the strongest-evidenced compound in this category — it holds a current FDA approval, marketed as Egrifta, for reduction of excess visceral abdominal fat in HIV-associated lipodystrophy. That specific indication is what the trials studied.
| Phase | Amount | Frequency | Notes |
|---|---|---|---|
| Approved use | 2 mg | Once daily, subcutaneous | The single approved amount for the labelled indication. |
Study length: Phase 3 trials ran 26 weeks with a 26-week extension. The label notes benefit is not maintained after discontinuation.
Reconstitution and measurement
This part is arithmetic and does not depend on the evidence level. Concentration is vial size divided by the bacteriostatic water you add. Draw volume is your target amount divided by that concentration. Units are draw volume times 100, because a U-100 syringe reads 100 units per millilitre. Common vials for Tesamorelin: 10 mg.
- Wipe the stoppers of both vials with an alcohol swab and let them dry.
- Draw the bacteriostatic water with a sterile syringe and inject it slowly down the inside wall of the peptide vial — never straight onto the powder.
- Swirl gently until the solution is clear. Do not shake; foaming and agitation damage peptides.
- Label the vial with the date and concentration, and refrigerate at 2–8 °C protected from light.
Worked example at the calculator defaults: 10 mg + 1 mL of bacteriostatic water = 10 mg/mL, so on a U-100 insulin syringe 1 unit = 100 mcg of Tesamorelin. Change either input and the calculator redoes this for you.
Storage and stability
Supplies math
Whatever amounts your research uses, the planning arithmetic is the same. The calculator runs all of this per compound.
Subcutaneous technique and practical notes
General best practice from clinical injection guidance — the same fundamentals nurses are taught, none of it specific to any compound.
Reported effects
- Trial reporting notes injection-site reactions, arthralgia and peripheral oedema.
- Because it raises IGF-1, the label carries monitoring guidance and contraindications including active malignancy.
- Visceral fat returned toward baseline after stopping in the extension study.
Sourcing Tesamorelin
Whatever you are working with, the documentation matters more than the price. Ask for a batch certificate of analysis whose lot number matches the vial you actually receive — a COA for a different batch tells you nothing about yours.
Tesamorelin at Summit Research Supply → Grade a COA first
Summit is the supplier we feature and an affiliate link. Our COA checklist applies the same way to any vendor.
