Ipamorelin protocol
Ipamorelin (selective growth hormone secretagogue). Dosing on this page comes from a published human trial or an approved product label, cited below.
How Ipamorelin works
A pentapeptide agonist at the ghrelin receptor (GHS-R1a). Its selling point in the literature is selectivity — unlike earlier secretagogues it releases GH without meaningfully raising cortisol or prolactin.
Ipamorelin dosing schedule
From the phase 2 proof-of-concept trial in postoperative ileus, which is the compound’s main human trial. Read the result alongside the schedule: ipamorelin did not separate from placebo on the primary endpoint. Median time to first tolerated meal was 25.3 hours versus 32.6 hours for placebo, which did not reach significance (p = 0.15).
| Phase | Amount | Frequency | Notes |
|---|---|---|---|
| Trial arm | 0.03 mg/kg | Twice daily, intravenous infusion | The only amount studied. 114 patients in the safety and modified intent-to-treat populations. |
Study length: Postoperative day 1 through day 7 or hospital discharge, whichever came first.
Reconstitution and measurement
This part is arithmetic and does not depend on the evidence level. Concentration is vial size divided by the bacteriostatic water you add. Draw volume is your target amount divided by that concentration. Units are draw volume times 100, because a U-100 syringe reads 100 units per millilitre. Common vials for Ipamorelin: 10 mg.
- Wipe the stoppers of both vials with an alcohol swab and let them dry.
- Draw the bacteriostatic water with a sterile syringe and inject it slowly down the inside wall of the peptide vial — never straight onto the powder.
- Swirl gently until the solution is clear. Do not shake; foaming and agitation damage peptides.
- Label the vial with the date and concentration, and refrigerate at 2–8 °C protected from light.
Worked example at the calculator defaults: 10 mg + 2 mL of bacteriostatic water = 5 mg/mL, so on a U-100 insulin syringe 1 unit = 50 mcg of Ipamorelin. Change either input and the calculator redoes this for you.
Storage and stability
Supplies math
Whatever amounts your research uses, the planning arithmetic is the same. The calculator runs all of this per compound.
Subcutaneous technique and practical notes
General best practice from clinical injection guidance — the same fundamentals nurses are taught, none of it specific to any compound.
Reported effects
- Reported as well tolerated in the phase 2 trial, with no significant safety signal against placebo.
- Efficacy was not demonstrated for the indication studied.
- The selectivity claim — GH release without cortisol or prolactin elevation — comes from earlier pharmacology work rather than this trial.
Sourcing Ipamorelin
Whatever you are working with, the documentation matters more than the price. Ask for a batch certificate of analysis whose lot number matches the vial you actually receive — a COA for a different batch tells you nothing about yours.
Ipamorelin at Summit Research Supply → Grade a COA first
Summit is the supplier we feature and an affiliate link. Our COA checklist applies the same way to any vendor.
