Glutathione protocol
Glutathione (reduced L-glutathione). Dosing on this page comes from a published human trial or an approved product label, cited below.
How Glutathione works
The body’s principal intracellular antioxidant, a tripeptide of glutamate, cysteine and glycine. Oral glutathione is largely broken down before absorption, which is why the human trial work uses intravenous administration.
Glutathione dosing schedule
From the controlled trials of intravenous glutathione in Parkinson’s disease, which are the best-designed human dosing studies available for injected glutathione. Both the indication and the route are specific — this is not evidence for cosmetic or general-wellness use.
| Phase | Amount | Frequency | Notes |
|---|---|---|---|
| Controlled trial arm | 1400 mg | Three times weekly, intravenous | The amount used in the placebo-controlled Parkinson’s trial work. |
Study length: Four weeks in the placebo-controlled work, with an open-label extension in some studies.
Reconstitution and measurement
This part is arithmetic and does not depend on the evidence level. Concentration is vial size divided by the bacteriostatic water you add. Draw volume is your target amount divided by that concentration. Units are draw volume times 100, because a U-100 syringe reads 100 units per millilitre. Common vials for Glutathione: 1500 mg.
- Wipe the stoppers of both vials with an alcohol swab and let them dry.
- Draw the bacteriostatic water with a sterile syringe and inject it slowly down the inside wall of the peptide vial — never straight onto the powder.
- Swirl gently until the solution is clear. Do not shake; foaming and agitation damage peptides.
- Label the vial with the date and concentration, and refrigerate at 2–8 °C protected from light.
Worked example at the calculator defaults: 1500 mg + 15 mL of bacteriostatic water = 100 mg/mL, so on a U-100 insulin syringe 1 unit = 1 mg of Glutathione. Change either input and the calculator redoes this for you.
Storage and stability
Supplies math
Whatever amounts your research uses, the planning arithmetic is the same. The calculator runs all of this per compound.
Subcutaneous technique and practical notes
General best practice from clinical injection guidance — the same fundamentals nurses are taught, none of it specific to any compound.
Reported effects
- Trial reporting describes intravenous glutathione as generally well tolerated at the amounts studied.
- The Parkinson’s trials did not demonstrate a convincing clinical benefit over placebo.
- Skin-lightening use, which drives much of the demand, has been the subject of regulatory safety warnings and is not supported by controlled evidence.
Sourcing Glutathione
Whatever you are working with, the documentation matters more than the price. Ask for a batch certificate of analysis whose lot number matches the vial you actually receive — a COA for a different batch tells you nothing about yours.
Glutathione at Summit Research Supply → Grade a COA first
Summit is the supplier we feature and an affiliate link. Our COA checklist applies the same way to any vendor.
