BPC-157 protocol
BPC-157 (Body Protection Compound 157). The published work on this compound is animal or cell-culture research. No human dosing schedule exists to cite.
Protocol overview
How BPC-157 works
A synthetic pentadecapeptide derived from a sequence found in human gastric juice. Rodent work reports accelerated tendon, muscle and gut healing, with effects on angiogenesis and nitric-oxide signalling proposed as mechanisms.
BPC-157 dosing — what the literature actually supports
We publish a schedule when there is a citable human source and we say so when there is not. Filling this space with a number nobody measured would make the page look more complete and be worth less than nothing to you.
What the published studies actually administered
These are the amounts that appear in the actual published work, reported as published. They are animal doses and cell-culture concentrations, not human protocols.
| Work | Amount used | Route | Context |
|---|---|---|---|
| Rodent injury models (Sikiric group, dozens of papers) | 10 ng/kg or 10 μg/kg, typically once daily | Intraperitoneal, intragastric, or topical by model | The two canonical doses repeated across the gut, tendon, muscle and vessel studies |
| Tendon fibroblast work (Chang 2011) | ng/mL to μg/mL in culture medium | In vitro | Concentrations in a dish, not doses in a body |
Reconstitution and measurement
This part is arithmetic and does not depend on the evidence level. Concentration is vial size divided by the bacteriostatic water you add. Draw volume is your target amount divided by that concentration. Units are draw volume times 100, because a U-100 syringe reads 100 units per millilitre. Common vials for BPC-157: 10, 20 mg.
- Wipe the stoppers of both vials with an alcohol swab and let them dry.
- Draw the bacteriostatic water with a sterile syringe and inject it slowly down the inside wall of the peptide vial — never straight onto the powder.
- Swirl gently until the solution is clear. Do not shake; foaming and agitation damage peptides.
- Label the vial with the date and concentration, and refrigerate at 2–8 °C protected from light.
Worked example at the calculator defaults: 10 mg + 2 mL of bacteriostatic water = 5 mg/mL, so on a U-100 insulin syringe 1 unit = 50 mcg of BPC-157. Change either input and the calculator redoes this for you.
Storage and stability
Supplies math
Whatever amounts your research uses, the planning arithmetic is the same. The calculator runs all of this per compound.
Subcutaneous technique and practical notes
General best practice from clinical injection guidance — the same fundamentals nurses are taught, none of it specific to any compound.
Reported effects
- Rodent models consistently report accelerated healing of tendon, ligament, muscle and gut injuries — this is the core of the literature, and it is animal data.
- Anti-inflammatory and cytoprotective activity reported across preclinical injury models.
- No human safety data from controlled trials.
- Rodent studies consistently report a wide therapeutic window with little observed toxicity, which is not the same as human safety.
- In 2022 BPC-157 was added to prohibited-substance monitoring in sport, which is worth knowing if you are tested.
The part that isn't a peptide
None of the literature above was run on a background of poor sleep and no protein. Whatever the research question, these variables move outcomes more reliably than any compound on this site.
- Tendon and muscle models in the literature pair the compound with controlled loading — tissue adapts to progressive load, and no rodent study used bed rest as the protocol.
- Protein intake and overall energy availability set the ceiling on any repair process being studied.
- Sleep is when most tissue-repair signalling happens; it is the cheapest variable in the whole model.
- For an actual injury, a qualified clinician and a rehab plan are the intervention with human evidence behind them.
Sourcing BPC-157
Whatever you are working with, the documentation matters more than the price. Ask for a batch certificate of analysis whose lot number matches the vial you actually receive — a COA for a different batch tells you nothing about yours.
BPC-157 at Summit Research Supply → Grade a COA first
Summit is the supplier we feature and an affiliate link. Our COA checklist applies the same way to any vendor.
Sources and further reading
- Sikiric P, et al. Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract. Current Pharmaceutical Design, 2011. — find on PubMed
- Chang CH, et al. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. Journal of Applied Physiology, 2011. — find on PubMed
- Seiwerth S, et al. BPC 157 and blood vessels. Current Pharmaceutical Design, 2014. — find on PubMed
- Vukojevic J, et al. Rat inferior caval vein occlusion and BPC 157 (vascular recruitment). Vascular Pharmacology, 2018. — find on PubMed
Broader literature searches:
