Kisspeptin-10 protocol
Kisspeptin-10 (KISS1-derived neuropeptide). Dosing on this page comes from a published human trial or an approved product label, cited below.
How Kisspeptin-10 works
The product of the KISS1 gene and the upstream trigger of the reproductive axis: it stimulates GnRH release from the hypothalamus, which drives LH and FSH. It is the master switch that puberty depends on.
Kisspeptin-10 dosing schedule
From the human physiology research programme, principally at Imperial College London, which has studied kisspeptin in reproductive endocrinology and as a trigger in IVF. These are controlled infusion studies designed to probe the reproductive axis, not a treatment protocol — and administration is intravenous infusion dosed per kilogram per hour, which does not translate to a subcutaneous injection.
| Phase | Amount | Frequency | Notes |
|---|---|---|---|
| Research infusion | Dosed per kg per hour | Continuous intravenous infusion | Kisspeptin-10 has a half-life of minutes, so the research work uses infusion rather than bolus injection. |
| IVF trigger studies | Single bolus, kisspeptin-54 | Subcutaneous, in trial settings | The IVF trigger work largely used kisspeptin-54, a different and longer-acting form than kisspeptin-10. |
Study length: Single infusions or short protocols within research and IVF-trigger settings.
Reconstitution and measurement
This part is arithmetic and does not depend on the evidence level. Concentration is vial size divided by the bacteriostatic water you add. Draw volume is your target amount divided by that concentration. Units are draw volume times 100, because a U-100 syringe reads 100 units per millilitre. Common vials for Kisspeptin-10: 10 mg.
- Wipe the stoppers of both vials with an alcohol swab and let them dry.
- Draw the bacteriostatic water with a sterile syringe and inject it slowly down the inside wall of the peptide vial — never straight onto the powder.
- Swirl gently until the solution is clear. Do not shake; foaming and agitation damage peptides.
- Label the vial with the date and concentration, and refrigerate at 2–8 °C protected from light.
Worked example at the calculator defaults: 10 mg + 2 mL of bacteriostatic water = 5 mg/mL, so on a U-100 insulin syringe 1 unit = 50 mcg of Kisspeptin-10. Change either input and the calculator redoes this for you.
Storage and stability
Supplies math
Whatever amounts your research uses, the planning arithmetic is the same. The calculator runs all of this per compound.
Subcutaneous technique and practical notes
General best practice from clinical injection guidance — the same fundamentals nurses are taught, none of it specific to any compound.
Reported effects
- Reported as well tolerated in the controlled research settings where it has been studied.
- The very short half-life of kisspeptin-10 is the central practical fact — it is why the human work uses infusions, and why a subcutaneous injection is not the same intervention.
- Kisspeptin-10 and kisspeptin-54 are not interchangeable.
Sourcing Kisspeptin-10
Whatever you are working with, the documentation matters more than the price. Ask for a batch certificate of analysis whose lot number matches the vial you actually receive — a COA for a different batch tells you nothing about yours.
Kisspeptin-10 at Summit Research Supply → Grade a COA first
Summit is the supplier we feature and an affiliate link. Our COA checklist applies the same way to any vendor.
